Ototoxicité des aminoglycosides
نویسندگان
چکیده
منابع مشابه
Aminoglycosides: nephrotoxicity.
Aminoglycosides have long been one of the commonest causes of drug-induced nephrotoxicity (137). Although a clear recognition of the patientand treatment-related risk factors (91), combined with the once-a-day schedule and effective monitoring procedures (98), have definitely improved the situation over what prevailed in the early 1980s (115), we are still short of having brought the safety of ...
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Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity, established the foundation for once-daily...
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Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of lifethreatening infections (28). Their history begins in 1944 with streptomycin and was thereafter marked by the successive introduction of a series of milestone compounds (kanamycin, gentamicin, and tobramycin) which definitively established the usefulness of this class of antibiot...
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The attachment of alkyl and other hydrophobic groups to traditional antibacterial kanamycins and neomycins creates amphiphilic aminoglycosides with altered antimicrobial properties. In this review, we summarize the discovery of amphiphilic kanamycins that are antifungal, but not antibacterial, and that inhibit the growth of fungi by perturbation of plasma membrane functions. With low toxicities...
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Aminoglycoside is a potent antibiotic that stops the protein synthesis continuation by binding to the ribosomal decoding site. They are used to treat infection caused by the aerobic, gram-negative and certain gram-positive organisms. The most commonly used aminoglycoside is Gentamicin. Generally, single daily dosing of aminoglycosides is appeared to be safer, cost effective and efficacious. Pro...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 1988
ISSN: 1958-5381,0767-0974
DOI: 10.4267/10608/3745